When people stop opening emails, it often means they lost interest or their needs changed. It's better to re-engage them gently before removing them. You can try sending a "we miss you" message or asking if they still want to receive updates. Sometimes a small incentive like a discount or exclusive content can bring them back. However, if they keep ignoring your emails, it's wise to clean your list so you only contact people who care about your content. This improves your email results and reduces spam complaints. How often do you think re-engagement emails should be sent before deciding to remove inactive contacts?