I would compare search intent alignment, checking which cluster better matches the product or content I can actually serve. Then I'd look at expected click-through value, like whether results lead to conversions, sign-ups, or engagement. Traffic volume and trend stability matter too, since a slightly harder cluster might be worth it if demand is growing. I'd also scan SERP features to see which is easier to compete in visually. Finally, I'd prioritize the cluster that builds stronger topical authority faster while offering clearer content gaps I can fill confidently.